Author : L. K. Omray [ Volume No.:V, Issue No.IV-July 2016] [Page No : 635-642] [2016]

The purpose of this research was to develop and evaluate transformation type liquid crystalline transdermal drug delivery system of propranolol in a form of gel. The reverse micelle lamellar transformation liquid crystals were prepared from lecithin, isopropyl myristate and propranolol. Prepared liquid crystalline transdermal gel was evaluated for anisotropy, vesicular size, polydispersity index, encapsulation efficiency, viscosity and in vitro drug release study. Formulations were observed under polarized microscopy and found to have liquid crystals on the basis of the presence of birefringence. Vesicular size of the liquid crystals formulation was found from 784 to 968 nm and polydispersity index was found from 0.51 to 0.78 among all developed five formulations. Entrapment efficiency and viscosity was found from 64.54 to 83.24% and from 1090 to 1420 cp respectively in all five formulations. In vitro release of all the formulations was performed and data were treated for release mechanism. All the formulations exhibited controlled release property and formulation PLC2 followed Peppas-Korsmeyer release pattern. It was concluded that final formulation may offer controlled transdermal delivery of propranolol as compared conventional therapy.